{"product_id":"high-purity-tb-500-peptide","title":"TB-500 (Thymosin Beta-4)","description":"\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eTB-500 | Thymosin Beta-4 Fragment | Research Peptide\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eSequence:\u003c\/strong\u003e Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln \u003cstrong\u003eMolecular Formula:\u003c\/strong\u003e C₅₀H₈₃N₁₅O₁₅ \u003cstrong\u003eMolecular Weight:\u003c\/strong\u003e 1114.25 g\/mol \u003cstrong\u003ePurity:\u003c\/strong\u003e \u0026gt;99% (HPLC verified) \u003cstrong\u003eForm:\u003c\/strong\u003e Lyophilised powder \u003cstrong\u003eAvailable Sizes:\u003c\/strong\u003e 5mg | 10mg \u003cstrong\u003eStorage:\u003c\/strong\u003e –20°C, away from light and moisture \u003cstrong\u003eCAS Number:\u003c\/strong\u003e 77591-33-4\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eWhat Is TB-500?\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eTB-500 is a synthetic analogue of Thymosin Beta-4 (Tβ4), a naturally occurring 43-amino-acid protein found in virtually all human and animal cells. TB-500 corresponds to the active region of Thymosin Beta-4 — specifically the actin-binding domain — which is widely considered to be the peptide's primary site of biological activity in preclinical models.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eThymosin Beta-4 was first isolated from bovine thymus tissue in the early 1980s and has since become one of the most studied members of the beta-thymosin family. TB-500, as the synthetic research variant, allows scientists to investigate the specific mechanisms attributed to Tβ4's active sequence without the complexity of working with the full protein.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eOur TB-500 is manufactured under stringent quality-controlled conditions, achieving a verified purity of greater than 99% as confirmed by High-Performance Liquid Chromatography (HPLC) and Mass Spectrometry (MS). It is supplied as a lyophilised (freeze-dried) powder to maximise stability during storage and shipping.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eResearch Background \u0026amp; Scientific Interest\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eTB-500 has been the subject of a significant and growing body of preclinical literature, with research spanning multiple disciplines including cellular biology, cardiovascular science, orthopaedics, and ophthalmology. Its primary mechanism of action centres on its ability to bind G-actin — a monomeric form of actin — thereby influencing cell migration, proliferation, and differentiation.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eActin Sequestration \u0026amp; Cell Motility\u003c\/strong\u003e The most well-characterised property of Thymosin Beta-4 and its analogues is G-actin sequestration. By binding to actin monomers, TB-500 regulates the dynamic polymerisation of the actin cytoskeleton. This action is understood to play a central role in cell migration and has made the compound of considerable interest in wound healing and tissue remodelling research.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eTissue Repair \u0026amp; Wound Healing Models\u003c\/strong\u003e TB-500 has been extensively studied in preclinical wound healing models. Research in rodent models has explored its influence on keratinocyte migration, dermal repair, and angiogenic signalling. Studies have demonstrated accelerated wound closure in animal models, attributed in part to the upregulation of key repair-associated proteins including VEGF (vascular endothelial growth factor) and matrix metalloproteinases (MMPs).\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eCardiovascular \u0026amp; Cardiac Research\u003c\/strong\u003e Some of the most compelling TB-500 preclinical data has emerged from cardiovascular research. Studies in animal cardiac injury models — including myocardial infarction — have investigated Thymosin Beta-4's influence on cardiomyocyte survival, angiogenesis, and cardiac progenitor cell activation. Researchers have observed cardioprotective responses and promotion of vasculogenesis in ischaemic tissue models, making this a particularly active area of investigation.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eMusculoskeletal \u0026amp; Connective Tissue Research\u003c\/strong\u003e TB-500 has attracted substantial interest in musculoskeletal research contexts. Preclinical studies have explored the peptide in models of tendon, ligament, and muscle injury, with findings suggesting modulation of inflammatory markers and support for extracellular matrix remodelling. Its apparent influence on skeletal muscle satellite cell activation has also been a focus of recent in vitro studies.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eAnti-inflammatory Activity\u003c\/strong\u003e Research has indicated that Thymosin Beta-4 may modulate NF-κB signalling — a master regulator of inflammatory gene expression. Preclinical studies have observed downregulation of pro-inflammatory cytokines including TNF-α and IL-1β in relevant models, suggesting a potential role in resolving acute and chronic inflammation that warrants continued scientific investigation.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cstrong\u003eNeurological Research\u003c\/strong\u003e An emerging area of TB-500 research concerns neuroregeneration. Early-stage preclinical studies have examined the peptide's effects in models of brain injury, spinal cord trauma, and neuroinflammation, with some findings pointing to neuroprotective and oligodendrocyte-promoting activity. This remains an exploratory frontier requiring further rigorous study.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eProduct Specifications\u003c\/h3\u003e\n\u003cdiv class=\"overflow-x-auto w-full px-2 mb-6\"\u003e\n\u003ctable class=\"min-w-full border-collapse text-sm leading-[1.7] whitespace-normal\"\u003e\n\u003cthead class=\"text-left\"\u003e\n\u003ctr\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eSpecification\u003c\/th\u003e\n\u003cth scope=\"col\" class=\"text-text-100 border-b-0.5 border-border-300\/60 py-2 pr-4 align-top font-bold\"\u003eDetail\u003c\/th\u003e\n\u003c\/tr\u003e\n\u003c\/thead\u003e\n\u003ctbody\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003ePeptide\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eTB-500 (Thymosin Beta-4 Analogue)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSequence\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAc-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003ePurity\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e\u0026gt;99% (HPLC \u0026amp; MS verified)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eForm\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eLyophilised powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eVial Sizes\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e5mg, 10mg\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eAppearance\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eWhite to off-white powder\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSolubility\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eSoluble in sterile water or PBS\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eStorage\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e–20°C, keep away from light\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eShelf Life\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e24 months when stored correctly (lyophilised)\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003ctr\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003eCAS Number\u003c\/td\u003e\n\u003ctd class=\"border-b-0.5 border-border-300\/30 py-2 pr-4 align-top\"\u003e77591-33-4\u003c\/td\u003e\n\u003c\/tr\u003e\n\u003c\/tbody\u003e\n\u003c\/table\u003e\n\u003c\/div\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eQuality \u0026amp; Purity Assurance\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eEvery batch of our TB-500 is subject to a comprehensive quality control process before it reaches researchers. Our assurance pipeline includes:\u003c\/p\u003e\n\u003cul class=\"[li_\u0026amp;]:mb-0 [li_\u0026amp;]:mt-1 [li_\u0026amp;]:gap-1 [\u0026amp;:not(:last-child)_ul]:pb-1 [\u0026amp;:not(:last-child)_ol]:pb-1 list-disc flex flex-col gap-1 pl-8 mb-3\"\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eHPLC Analysis\u003c\/strong\u003e — confirms peptide purity exceeding 99%\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eMass Spectrometry (MS)\u003c\/strong\u003e — verifies molecular identity, sequence accuracy, and molecular weight\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eEndotoxin Testing\u003c\/strong\u003e — ensures the product is free from bacterial endotoxins\u003c\/li\u003e\n\u003cli class=\"font-claude-response-body whitespace-normal break-words pl-2\"\u003e\n\u003cstrong\u003eCertificate of Analysis (CoA)\u003c\/strong\u003e — available for every batch upon request\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eWe maintain full traceability across our manufacturing and testing process, so researchers can rely on batch-to-batch consistency for reproducible experimental outcomes.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eHandling \u0026amp; Reconstitution (Research Use)\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eTB-500 lyophilised powder should be reconstituted using sterile bacteriostatic water or phosphate-buffered saline (PBS), depending on the experimental protocol. Gently swirl — do not vortex — to avoid disrupting peptide integrity. Once reconstituted, aliquot immediately and store at –20°C. Avoid repeated freeze-thaw cycles, as these can compromise peptide stability and reduce experimental reliability.\u003c\/p\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eAll handling should comply with standard laboratory safety protocols and applicable institutional or regulatory guidelines.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003eHow TB-500 Compares to BPC-157\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003eResearchers frequently study TB-500 and BPC-157 in parallel due to their overlapping areas of preclinical interest — particularly tissue repair and inflammation modelling. While BPC-157 is gastric in origin and primarily studied via the nitric oxide and growth hormone receptor pathways, TB-500 acts principally through actin sequestration and VEGF-mediated angiogenesis. Their distinct mechanisms make them complementary subjects in multi-peptide research protocols, and both are available in our catalogue.\u003c\/p\u003e\n\u003chr class=\"border-border-200 border-t-0.5 my-3 mx-1.5\"\u003e\n\u003ch3 class=\"text-text-100 mt-2 -mb-1 text-base font-bold\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003eImportant Notice\u003c\/span\u003e\u003c\/h3\u003e\n\u003cp class=\"font-claude-response-body break-words whitespace-normal leading-[1.7]\"\u003e\u003cspan style=\"color: rgb(255, 42, 0);\"\u003e\u003cstrong\u003eThis product is intended strictly for in vitro research and laboratory use only. TB-500 is not approved for human or veterinary use by the FDA, EMA, or any other regulatory authority. It is not a drug, supplement, or food product. This product must not be administered to humans or animals. By purchasing this product, the buyer confirms they are a qualified researcher and will use the compound solely for lawful scientific research purposes.\u003c\/strong\u003e\u003c\/span\u003e\u003c\/p\u003e","brand":"NEXYRALAB","offers":[{"title":"5mg","offer_id":59643106099534,"sku":null,"price":24.99,"currency_code":"GBP","in_stock":true},{"title":"10mg","offer_id":59643106132302,"sku":null,"price":34.99,"currency_code":"GBP","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/1035\/3351\/0990\/files\/tb-500-navy-v2_4f0e6c03-f788-4126-8760-5b08d2abd0f9.jpg?v=1781522289","url":"https:\/\/checkout.nexyralab.com\/products\/high-purity-tb-500-peptide","provider":"Nexyralab.com","version":"1.0","type":"link"}